De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, Adult males de har desuden en modsatrettet virkning, idet de også spærrer for andre opioiders virkning.Metadon er et naturligt opioid, som anvendes mod kroniske smerter. Midlet er meget langsomt udskilt fra kroppen igen, og bør derfor ikke anvendes
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